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Remodulin (injection)

Generic name: treprostinil (injection) [ tre-PROS-ti-nil ]
Brand name: Remodulin
Drug class: Agents for pulmonary hypertension

Medically reviewed by Drugs.com on Sep 11, 2023. Written by Cerner Multum.

What is Remodulin?

Remodulin dilates (widens) the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs.

Remodulin is used to treat pulmonary arterial hypertension (PAH). Remodulin improves your ability to exercise and can help prevent your condition from getting worse.

Remodulin may also be used for purposes not listed in this medication guide.

Remodulin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

An intravenous catheter may increase your risk of a serious infection called sepsis. If you use intravenous Remodulin, watch for symptoms such as: fever, flu symptoms, mouth and throat ulcers, rapid heart rate, or rapid and shallow breathing. Call your doctor right away if you have any of these conditions.

Remodulin may cause serious side effects. Call your doctor at once if you have:

Common side effects of Remodulin may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Remodulin side effects (more detail)

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Remodulin if you are allergic to it.

Tell your doctor if you have ever had:

Do not start or stop using Remodulin during pregnancy without your doctor's advice. It is important to properly control PAH during pregnancy because having this condition can harm both mother and baby. Tell your doctor right away if you become pregnant.

It may not be safe to breast-feed while using Remodulin. Ask your doctor about any risk.

How is Remodulin given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may need to use this medicine for many years.

You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.

Remodulin is given around the clock using an infusion pump attached to a catheter placed under your skin (subcutaneous) or into a vein (intravenous). A healthcare provider can teach you how to properly use the infusion pump by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Remodulin if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

You may need to mix Remodulin with a liquid (diluent). When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Call your doctor if your symptoms do not improve, or if they get worse.

You should not reduce your dose or stop using Remodulin suddenly. Stopping suddenly may make your condition worse.

To make sure there is no interruption in your treatment, you may need to have a back-up infusion pump, replacement batteries, and extra infusion sets. Get your prescription refilled before you run out of medicine completely.

Store unopened vials (bottles) of treprostinil at room temperature away from moisture and heat. Throw away a vial after 30 days of use, even if there is still medicine left inside.

After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the type of diluent used, and whether you store the mixture at room temperature or in a refrigerator. Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Detailed Remodulin dosage information

What happens if I miss a dose?

Because Remodulin is given around the clock, you should not miss a dose if you use the medicine properly. Call your doctor right away if your Remodulin therapy is interrupted for any reason.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe tingling or warmth under your skin, diarrhea, vomiting, or fainting.

What should I avoid while using Remodulin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Remodulin?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect Remodulin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Remodulin drug interactions (more detail)

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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